In the 1960s, the same JetStar was equipped with an electronic variable stability flight control system. Called then a General Purpose Airborne Simulator (GPAS), the aircraft could duplicate the flight characteristics of a wide variety of advanced aircraft and was used for supersonic transport and general aviation research and as a training and support system for Space Shuttle Approach and Landing Tests at Dryden in 1977.

In 1985, the JetStar's wings were modified with suction and spray devices in a laminar (smooth) air flow program to study ways of improving the flow of air over the wings of airliners. The program also studied ways of reducing the collection of ice and insects on airliner wings.