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Viewed from across the nearby water, the launch of Space Shuttle Endeavour fills the horizon. Liftoff at 5:22:49 p.m. EDT sent Endeavour and its crew of four, plus the Expedition 5 crew, on its way to the International space Station on mission STS-111. This mission marks the 14th Shuttle flight to the International Space Station and the third Shuttle mission this year. Mission STS-111 is the 18th flight of Endeavour and the 110th flight overall in NASA's Space Shuttle program.